The PA 800 plus Pharmaceutical Analysis System automates size separation of proteins and provides high-resolution, quantitative data, as compared to traditional labor-intensive slab gels.

The CE SDS-gel application has become the gold standard for protein purity analysis in biopharmaceutical laboratories. Denatured proteins can be reduced or left intact for separation and subsequent analysis.

Beckman Coulter's patented replaceable SDS-gel¹ consists of a polymer matrix that allows for:

▪ Quantitative and automated separation of proteins from 10-225kD

▪ Sensitivity equivalent to silver-stained gels when using LIF detection*

▪ High-resolution separation capability

PA 800 plus System Application Guides

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PA 800 plus SDS-MW Application Guide

Click here for more information on CE SDS-Gel Chemistries.

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¹(See US Patent # US7,381,317. Automating the process of gel replacement is disclosed in US Patent # USRE37,606.)

*Salas-Solano O., Tomlinson B., Du S., Parker M., Strahan A., Ma S. "Optimization and Validation of a Quantitative Capillary Electrophoresis Sodium Dodecyl Sulfate Method for Quality Control and Stability Monitoring of Monoclonal Antibodies." Analytical Chemistry 2006, 10.1021.

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