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Therapeutic proteins make up a rapidly growing segment of global pharmaceutical production. These complex molecules require accurate characterization of product purity, heterogeneity and identity. This includes data regarding their stability, shelf life and related manufacturing processes.

Automated and Quantitative Analysis of Biologics

The PA 800 plus Pharmaceutical Analysis System* was designed in collaboration with biopharmaceutical development and QC groups. This platform provides analysts with robust and easy-to-use characterization, integrating quantitative, qualitative and automated solutions for protein purity, charge isoform distribution and glycan analysis. During the design of the PA 800 plus, Beckman Coulter emphasized assay portability, enhancing the overall system utility in multi-user, multi-instrument facilities.

Click here to download the PA 800 plus Pharmaceutical Analysis System brochure.

Automated applications provide reproducible and quantitative results:
▪	High resolution SDS-gel separation for protein purity determination
▪	Advanced capillary Isoelectric Focusing (cIEF) for charge heterogeneity analysis
▪	Carbohydrate profiling for assessment of glycoprotein microheterogeneity

Simplified operations and a robust platform enhance operational efficiency:
▪	Specialized software quickly guides routine users from set-up through results
▪	Innovations in system design ensure dependable operation and durability, with minimal maintenance
▪	Modular UV, photodiode array and laser-induced fluorescence detectors can be easily interchanged

System Part Numbers

Click on the Part Number(s) below for Ordering Information.

Part Number	Description
A66528	*PA 800 plus* Pharmaceutical Analysis System** Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 plus software; system startup kit and reagents
A66527	*PA 800S plus* Pharmaceutical Analysis System** Includes separation module with photodiode array detection; system controller with PA 800 plus software; system startup kit and reagents

System Specifications

Weight	188 lb (85.3 kg)
Height	29.2 in (98.6 cm)
Depth	28.4 in (72.1)
Width with Door Open	25 in (63.5 cm)
Power Requirements	Voltage 100-240 V 50/60 Hz
Voltage Range	1 to 30 kV programmable at 0.1 kV Increments
Current Range	3 to 300 μA programmable at 0.1 μA Increments
Pressure Delivery Range	-5 to +100 psi
Sample Temperature Control	4°C - 60°C
Capillary Temperature Control	15°C - 60°C

*PA 800 plus* System Manuals**
▪	PA 800 plus System Overview
▪	PA 800 plus Maintenance Guide
▪	PA 800 plus Methods Development Guide
▪	PA 800 plus System Administrators Guide
▪	PA 800 plus Pre-Installation Guide
▪	PA 800 plus Software Validation Pack

* The lamp in this product contains mercury. Dispose according to local laws.

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